大孔交联聚甲基丙烯酸羟乙酯的制备及对胆红素的吸附研究

(西安工业大学 材料与化工学院,西安 710021

聚甲基丙烯酸羟乙酯; 胆甾型液晶; 胆红素; 吸附率

Synthesis of Crosslinked Macroporous Poly(Hydroxyethyl Methacrylate)and Its Absorption of Bilirubin
NIU Xiaoling,SUN Sijia

(School of Materials and Chemical Engineering,Xi'an Technological University,Xi'an 710021,China)

poly(hydroxyethyl methacrylate); cholesteric liquid crystal; bilirubin; absorption rate

DOI: 10.16185/j.jxatu.edu.cn.2019.06.002 http://xb.xatu.edu.cn

备注

为了提高聚甲基丙烯酸羟乙酯(PHEMA)对胆红素的吸附性,利用水相悬浮法分别引入不同质量分数ω(20%,30%和40%)的胆甾型液晶(CLC),制备大孔交联PHEMA。通过红外光谱仪(IR)对PHEMA进行结构分析,采用热台偏光显微镜(POM)和扫描电镜(SEM)观察PHEMA的微观形貌,且分别在不同pH、温度和白蛋白环境下,研究了PHEMA对胆红素的吸附作用。研究结果表明:CLC的含量影响PHEMA的孔洞结构,引入CLC可以提高PHEMA对胆红素的吸附性。随着温度的升高,PHEMA对胆红素的吸附率出现上升趋势,当温度升至35 ℃时,吸附率达到最高,当继续升温时,吸附率减小。随着pH的升高,PHEMA的吸附率先增加后降低,当pH为7.5时,吸附率达到最大。CLC的质量分数为20%和30%制备的PHEMA,其吸附达到平衡的时间比较快,在1 h内已基本达到平衡态,30 min内吸附率达到了30%左右。加入白蛋白后,吸附速度减慢,吸附平衡时间延长,PHEMA对胆红素的吸附率降低。

The study aims to improve poly(hydroxyethyl methacrylate)(PHEMA)'s absorption of bilirubin.PHEMA was synthesized with the addition of cholesteric liquid crystals(CLC)of different mass ratios(20%,30%,40%)by the aqueous suspension method.The structure of PHEMA was analyzed by an IR.The micro-morphology of PHEMA was characterized by a POM and a SEM.Its adsorption of bilirubin was respectively studied with different pH values and albumins and at different temperatures.The research indicates that the content of CLC affected the pore structure of PHEMA and that the addition of CLC improved PHEMA's adsorption rate.With an increase in temperature,PHEMA's adsorption rate tended to rise.When the temperature reached 35 ℃,the adsorption rate was the highest,and then declined when temperature continues increasing.With pH value increasing,the adsorption rate of PHEMA increased first and then decreased.The adsorption rate reached the maximum when the pH was 7.5.The absorption of the PHEMAs prepared with the addition of 20% and 30% CLC reached equilibrium faster,within 1 h.Their adsorption rate reached about 30% within 30 min.The addition of albumin slowed down the adsorption,prolonging the adsorption equilibrium,with the adsorption rate of Bilirubin decreased.